This is God-as-destroyer, and recalled, for me at least, Noah and the Great Flood.
An Earth-based God (the four elements) threatens to kill all humans, and Superman’s response is basically to say that he’d miss people, but he’d just go find another alien race to adopt as his own. (I’ll see your genocide and raise you one global destruction.)
In other words, without Lois Lane, humans seem to mean much, much less to Superman. This helps explain why he refuses to cure Father Leone’s cancer in #210…
Superman “says” that he won’t cure cancer because, if he was able to, humans would expect too much of him. But is that really what’s going on here? I mean, if he can then why not do it? He’s already stopped wars and saved the universe hundreds of times. In fact, he was out saving another galaxy—a million miles away—when Lois was vanished.